UNC5H3/UNC5C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-37002

Novus Biologicals, part of Bio-Techne
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NBP1-37002
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all UNC5H3 Antibodies »

Product Specifications

Immunogen

Peptide with sequence NCTVSEEPTGID corresponding to internal region according to NP_003719.2.

Epitope

NCTVSEEPTGID

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for UNC5H3/UNC5C Antibody

Immunocytochemistry/ Immunofluorescence: UNC5H3/UNC5C Antibody [NBP1-37002]

Immunocytochemistry/ Immunofluorescence: UNC5H3/UNC5C Antibody [NBP1-37002]

Immunocytochemistry/Immunofluorescence: UNC5H3/UNC5C Antibody [NBP1-37002] - Staining of islets in Mouse Pancreas. Citrate antigen retrieval. Detected by immunofluorescence.
Immunohistochemistry-Paraffin: UNC5H3/UNC5C Antibody [NBP1-37002]

Immunohistochemistry-Paraffin: UNC5H3/UNC5C Antibody [NBP1-37002]

Immunohistochemistry-Paraffin: UNC5H3/UNC5C Antibody [NBP1-37002] - Staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for UNC5H3/UNC5C Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Immunohistochemistry

3 - 5 ug/ml

Immunohistochemistry-Paraffin

3 - 5 ug/ml

Peptide ELISA

Detection limit 1:32000
Application Notes
IF: An anonymous customer has reported staining of paraffin embedded endocrine islets (red), nuclear (blue), and ductal cell (green) in adult mouse pancreas. WB: Preliminary experiments in human and mouse brain lysates gave no specific signal but low background. IHC-P: Human cerebral cortex shows staining of some neuronal bodies plus intense axonal staining.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: UNC5H3

UNC5C is a gene that codes for a protein that is the receptor for netrin that is required for axon guidance, as it mediates the axon repulsion of neuronal growth cones when there is ligand binding in the nervous system, and can also help to induce apoptosis. The protein encoded by UNC5C has two isoforms, with lengths of 931 and 597 amino acids and weights of approximately 103 and 66 kDa respectively. Current studies are being done on diseases and disorders related to this gene including colorectal cancer, renal cell carcinoma, rheumatoid arthritis, Parkinson's disease, kidney cancer, colon cancer, osteoarthritis, schizophrenia, and neuronitis. UNC5C has also been shown to have interactions with NTN1, PTPN11, DAPK1, DCC, and FYN in pathways such as the netrin signaling and axon guidance pathways.

Long Name

Netrin Receptor UNC5C

Alternate Names

UNC5C

Entrez Gene IDs

8633 (Human); 22253 (Mouse)

Gene Symbol

UNC5C

UniProt

NP_003719.2 (Human)

Additional UNC5H3 Products

Product Documents for UNC5H3/UNC5C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for UNC5H3/UNC5C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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