VAChT/SLC18A3 Antibody - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-61675

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB110-61675
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Rat, Guinea Pig

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all VAChT/SLC18A3 Antibodies »

Product Specifications

Immunogen

Synthetic peptide (CTRSRSERDVLLDEPPQGLYDAVRLRE) as part of rat Vesicular Acetylcholine Transporter. VACHT (accession: NP_113851) conjugated to Blue Carrier protein.

Reactivity Notes

This antibody is reactive against rat and guinea pig. Not yet tested in other species.

Specificity

Confirmed by immunohistochemical analysis of Guinea pig gut. Specific detection in neurons and glial cells.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for VAChT/SLC18A3 Antibody - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Reconstitution

Reconstitute with 0.02 ml sterilized water.

Formulation

0.05X PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

Background: VAChT/SLC18A3

Vesicular Acetylcholine Transporter (VAChT), (~70kD protein), belongs to the family of vesicular monoamine transporters(VMATs), which include VMAT1 and VMAT2 and the C.elegans putative ACh transporter unc-17. Members of this family function to concentrate neurotransmitters into synaptic vesicles through exchange of protons for neurotransmitters. VAChT is a functional transporter for the neurotransmitter acetylcholine(ACh). ACh is synthesized in the cytoplasm by choline acetyl transferase (ChAT) and transported by VAChT into synaptic vesicles where it is stored until released. After release from presynaptic nerve terminals ACh is hydrolyzed by extracellular ACh-esterases(AChE) to choline and acetate. VAChT mRNA is expressed in all known major cholinergic neurons in the central and peripheral nervous system. VAChT is abundantly expressed in the CNS and is mainly localized in small synaptic vesicles in cholinergic nerve terminals. VAChT provides a specific marker for cholinergic neurons for the study of cholinergic transmission in experimental models, in Alzheimer's disease and other nervous system disorders.

Long Name

Vesicular Acetylcholine Transporter/Solute Carrier Family 18 Member 3

Alternate Names

SLC18A3

Entrez Gene IDs

60422 (Rat)

Gene Symbol

SLC18A3

Additional VAChT/SLC18A3 Products

Product Documents for VAChT/SLC18A3 Antibody - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for VAChT/SLC18A3 Antibody - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.