VAP-1/AOC3 Antibody (7-88)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-58374

Novus Biologicals, part of Bio-Techne
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NBP1-58374
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Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, Functional, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2B Clone # 7-88

Concentration

0.1 mg/ml

View all VAP-1/AOC3 Antibodies »

Product Specifications

Immunogen

Vessels from mouse lymph nodes

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Description

Positive Control: Mouse VAP-1-transfected CHO cells (ref. 2) Negative control: Mock-transfected CHO cells (Ref. 2)

Scientific Data Images for VAP-1/AOC3 Antibody (7-88)

Immunohistochemistry-Frozen: VAP-1/AOC3 Antibody (7-88) [NBP1-58374]

Immunohistochemistry-Frozen: VAP-1/AOC3 Antibody (7-88) [NBP1-58374]

Immunohistochemistry-Frozen: VAP1 Antibody (7-88) [NBP1-58374] - VAP-1 expression in mouse muscle tissue; frozen sections.

Applications for VAP-1/AOC3 Antibody (7-88)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunocytochemistry/ Immunofluorescence

1:10-1:500

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Immunoprecipitation

1:10-1:500
Application Notes
This antibody works in Flow Cytometry, Functional, Immunofluorescence, Immunohistochemistry-Frozen, Immunoprecipitation

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.2 um filtered solution in PBS and 0.1% BSA

Preservative

No Preservative

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: VAP-1/AOC3

The monoclonal antibody 7-88 recognizes mouse Vascular Adhesion Protein-1 (VAP-1) which is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is expressed in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end-products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. In white adipose tissue of obese and diabetic db-/- mice increased expression of VAP-1 has been observed suggesting that it contributes to the arthrosclerosis and vascular dysfunction observed in these diseases. Moreover, inhibition of VAP-1reduced the accumulation of myeloid cells into tumors and attenuates tumor growth. The monoclonal antibody 7-88 inhibits migration of granulocytes and monocytes in acute models of inflammation.

Long Name

Vascular Adhesion Protein-1

Alternate Names

AOC3, HPAO, SSAO, VAP1

Gene Symbol

AOC3

Additional VAP-1/AOC3 Products

Product Documents for VAP-1/AOC3 Antibody (7-88)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for VAP-1/AOC3 Antibody (7-88)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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