VAV3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-29818

Novus Biologicals, part of Bio-Techne
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NBP3-29818
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Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all VAV3 Antibodies »

Product Specifications

Immunogen

Between 200 and 250

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for VAV3 Antibody

VAV3 Antibody

Immunoprecipitation:VAV3 AntibodyNBP3-29818] -

Immunoprecipitation:VAV3 AntibodyNBP3-29818] -Detection of human VAV3 by western blot of immunoprecipitation. Samples: Whole cell lysate (50 µg for input; 1 mg for IP, 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-VAV3 antibody NBP3-29818 used for WB at 1 µg/ml and used for IP at 6 µg/mg lysate. VAV3 was also immunoprecipitated by rabbit anti-VAV3 antibody , which recognizes a downstream epitope. Detection: Chemiluminescence with an exposure time of 3 minutes.

Applications for VAV3 Antibody

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Tris-citrate/phosphate buffer, pH 7 to 8

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: VAV3

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). Vav3 is expressed in most hematopoietic cells and non-hematopoietic tissues except ovary and skeletal muscles. T-cell stimulated and tyrosine phosphorylated Vav3 acts as an exchange factor for GTP-binding proteins RhoA, RhoG, and Rac1 (2). Also, tyrosine phosphorylated Vav3 mediates RTK signalizing, specifically IR, IGFR, and EGFR-mediated signaling pathways. Vav3 has been linked to as a factor for cell morphology modulation and an inducer for cell transformation (3).

Alternate Names

FLJ40431, guanine nucleotide exchange factor VAV3, vav 3 guanine nucleotide exchange factor, vav 3 oncogene, VAV-3

Gene Symbol

VAV3

Additional VAV3 Products

Product Documents for VAV3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for VAV3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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