WNK4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-92597

Novus Biologicals, part of Bio-Techne
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NBP1-92597
NBP1-92597-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all WNK4 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAEL

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (87%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for WNK4 Antibody

Immunohistochemistry: WNK4 Antibody [NBP1-92597]

Immunohistochemistry: WNK4 Antibody [NBP1-92597]

Immunohistochemistry: WNK4 Antibody [NBP1-92597] - Staining of human kidney shows strong cytoplasmic and nuclear positivity in cells in tubules.

Applications for WNK4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: WNK4

WNK lysine deficient protein kinase 4 (WNK4) is a cytoplasmic serine-threonine kinase expressed in the distal nephron which likely plays an important role in hypertension. The role of WNK4 in kidney physiology is to act as a molecular switch between NaCl reabsorption (volume retention) and K+ secretion (waste release).

WNK4 mutations have been associated with an autosomal dominant disease called pseudohypoaldosteronism type II.

Alternate Names

EC 2.7.11, EC 2.7.11.1, PHA2B, PRKWNK4protein kinase, lysine deficient 4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4, serine/threonine-protein kinase WNK4, WNK lysine deficient protein kinase 4

Gene Symbol

WNK4

Additional WNK4 Products

Product Documents for WNK4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for WNK4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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