WRN Antibody (3C11)

Novus Biologicals, part of Bio-Techne | Catalog # H00007486-M09

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 3C11

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all WRN Antibodies »

Product Specifications

Immunogen

WRN (NP_000544, 1322 a.a. ~ 1432 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. NPPVNSDMSKISLIRMLAPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Specificity

WRN (3C11)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for WRN Antibody (3C11)

Western Blot: WRN Antibody (3C11) [H00007486-M09]

Western Blot: WRN Antibody (3C11) [H00007486-M09]

Western Blot: WRN Antibody (3C11) [H00007486-M09] - Analysis of WRN expression in Hela S3 NE (Cat # L013V3).
Immunocytochemistry/ Immunofluorescence: WRN Antibody (3C11) [H00007486-M09]

Immunocytochemistry/ Immunofluorescence: WRN Antibody (3C11) [H00007486-M09]

Immunocytochemistry/Immunofluorescence: WRN Antibody (3C11) [H00007486-M09] - Analysis of monoclonal antibody to WRN on HeLa cell. Antibody concentration 10 ug/ml
ELISA: WRN Antibody (3C11) [H00007486-M09]

ELISA: WRN Antibody (3C11) [H00007486-M09]

ELISA: WRN Antibody (3C11) [H00007486-M09] - Detection limit for recombinant GST tagged WRN is approximately 0.3ng/ml as a capture antibody.

Applications for WRN Antibody (3C11)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: WRN

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Long Name

Werner syndrome ATP-dependent helicase

Alternate Names

EC 3.1.-.-, Exonuclease WRN, RecQ protein-like 2, RecQ3, RECQL2

Entrez Gene IDs

7486 (Human)

Gene Symbol

WRN

OMIM

277700 (Human)

UniProt

NP_000544 (Human)

Additional WRN Products

Product Documents for WRN Antibody (3C11)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for WRN Antibody (3C11)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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