XPE/DDB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38854

Novus Biologicals, part of Bio-Techne
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NBP2-38854-25ul
NBP2-38854
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all XPE/DDB2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: GPSRRCDSDCLWVGLAGPQILPPCRSIVRTLHQHKLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for XPE/DDB2 Antibody

Immunohistochemistry-Paraffin: XPE/DDB2 Antibody [NBP2-38854]

Immunohistochemistry-Paraffin: XPE/DDB2 Antibody [NBP2-38854]

Immunohistochemistry-Paraffin: XPE/DDB2 Antibody [NBP2-38854] - Analysis in human esophagus and skeletal muscle tissues. Corresponding DDB2 RNA-seq data are presented for the same tissues.
Immunocytochemistry/ Immunofluorescence: XPE/DDB2 Antibody [NBP2-38854]

Immunocytochemistry/ Immunofluorescence: XPE/DDB2 Antibody [NBP2-38854]

Immunocytochemistry/Immunofluorescence: XPE/DDB2 Antibody [NBP2-38854] - Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & cell junctions. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: XPE/DDB2 Antibody [NBP2-38854]

Immunohistochemistry-Paraffin: XPE/DDB2 Antibody [NBP2-38854]

Immunohistochemistry-Paraffin: XPE/DDB2 Antibody [NBP2-38854] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
View 2 more images

Applications for XPE/DDB2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: XPE/DDB2

DDB2, also known as DNA damage-binding protein 2, consists of five isoforms of sizes 47.9 kDa, 26.7 kDa, 17.4 kDa, 40.7 kDa, and 26.8 kDa and is involved in repairing DNA damaged by ultraviolet light. Current research is being conducted on disorders and diseases including immunodeficiency, hepatitis, multiple sclerosis, lung cancer, ovarian cancer, skin cancer, and autosomal recessive disease. The protein has been linked to DNA repair and protein stability pathways where it interacts with CUL4A, DDB1, COPS5, ABL1, and E2F1.

Long Name

Xeroderma Pigmentosum E

Alternate Names

DDB2, XP5

Gene Symbol

DDB2

UniProt

Q92466

Additional XPE/DDB2 Products

Product Documents for XPE/DDB2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for XPE/DDB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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