ZCCHC11/TUT4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00023318-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ZCCHC11/TUT4 Antibodies »

Product Specifications

Immunogen

ZCCHC11 (AAH48301.1, 1 a.a. - 309 a.a.) full-length human protein. MEESKTLKSENHEPKKNVICEESKAVQVIGNQTLKARNDKSVKEIENSSPNRNSSKKNKQNDICIEKTEVKSCKVNAANLPGPKDLGLVLRDQSHCKAKKFPNSPVKAEKATISQAKSEKATSLQAIAEKSPKSPNSVKAEKASSYQMKSEKVPSSPAEAEKGPSLLLKDMRQKTELQQIGKKIPSSFTSVDKVNIEAVGGEKCALQNSPRSQKQQTCTDNTGDSDDSASGIEDVSDDLSKMKNDESNKENSSEMDYLENATVIDESALTPEQRLGLKQAEERLERDHIFRLEKVYYVVLVIWGEMCVS

Specificity

Reacts with zinc finger, CCHC domain containing 11.

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for ZCCHC11/TUT4 Antibody

Western Blot: ZCCHC11/TUT4 Antibody [H00023318-B01P]

Western Blot: ZCCHC11/TUT4 Antibody [H00023318-B01P]

Western Blot: ZCCHC11/TUT4 Antibody [H00023318-B01P] - Analysis of ZCCHC11 expression in human spleen.
Western Blot: ZCCHC11/TUT4 Antibody [H00023318-B01P]

Western Blot: ZCCHC11/TUT4 Antibody [H00023318-B01P]

Western Blot: ZCCHC11/TUT4 Antibody [H00023318-B01P] - Analysis of ZCCHC11 expression in transfected 293T cell line by ZCCHC11 polyclonal antibody. Lane 1: ZCCHC11 transfected lysate(33.99 KDa). Lane 2: Non-transfected lysate.

Applications for ZCCHC11/TUT4 Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is reactive against tissue and transfected lysate in western blot, and as a detection antibody in ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ZCCHC11/TUT4

Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation

Alternate Names

DKFZp779C1943, EC 2.7.7.52, KIAA0191FLJ42878, PAP associated domain containing 3, PAPD3, terminal uridylyltransferase 4, TUT4, TUTase 4, Zinc finger CCHC domain-containing protein 11, zinc finger, CCHC domain containing 11

Entrez Gene IDs

23318 (Human)

Gene Symbol

TUT4

Additional ZCCHC11/TUT4 Products

Product Documents for ZCCHC11/TUT4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ZCCHC11/TUT4 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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