ZCCHC11/TUT4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-83027

Novus Biologicals, part of Bio-Techne
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NBP1-83027
NBP1-83027-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ZCCHC11/TUT4 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: CNCIDLSKSPDPDKSTGTDCRSNLETESSHQSVCTDTSATSCNCKATEDASDLNDDDNLPTQELYYVFDKFILTSGK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ZCCHC11/TUT4 Antibody

Immunocytochemistry/ Immunofluorescence: ZCCHC11/TUT4 Antibody [NBP1-83027]

Immunocytochemistry/ Immunofluorescence: ZCCHC11/TUT4 Antibody [NBP1-83027]

Immunocytochemistry/Immunofluorescence: ZCCHC11/TUT4 Antibody [NBP1-83027] - Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
Immunohistochemistry-Paraffin: ZCCHC11/TUT4 Antibody [NBP1-83027]

Immunohistochemistry-Paraffin: ZCCHC11/TUT4 Antibody [NBP1-83027]

Immunohistochemistry-Paraffin: ZCCHC11/TUT4 Antibody [NBP1-83027] - Staining of human smooth muscle shows distinct cytoplasmic positivity.

Applications for ZCCHC11/TUT4 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ZCCHC11/TUT4

Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation

Alternate Names

DKFZp779C1943, EC 2.7.7.52, KIAA0191FLJ42878, PAP associated domain containing 3, PAPD3, terminal uridylyltransferase 4, TUT4, TUTase 4, Zinc finger CCHC domain-containing protein 11, zinc finger, CCHC domain containing 11

Gene Symbol

TUT4

Additional ZCCHC11/TUT4 Products

Product Documents for ZCCHC11/TUT4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ZCCHC11/TUT4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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