ZFYVE26 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76331

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (94%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all ZFYVE26 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15. Amino Acid Squence: KALDFPYPQREKRSDS

Specificity

Multiple isoforms of SPG15 are known to exist.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

260 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ZFYVE26 Antibody - BSA Free

Western Blot: ZFYVE26 AntibodyBSA Free [NBP1-76331]

Western Blot: ZFYVE26 AntibodyBSA Free [NBP1-76331]

Western Blot: ZFYVE26 Antibody [NBP1-76331] - Analysis in K562 cell lysate with antibody at (A) 1 and (B) 2 ug/mL.
ZFYVE26 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: ZFYVE26 Antibody - BSA Free [NBP1-76331] -

Immunocytochemistry/ Immunofluorescence: ZFYVE26 Antibody - BSA Free [NBP1-76331] - Immunofluorescence of ZFYVE26 in Mouse Heart tissue with ZFYVE26 antibody at 20 u/mL.

Applications for ZFYVE26 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ZFYVE26

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.

Alternate Names

DKFZp686F19106, DKFZp781H1112, FYVE domain-containing centrosomal protein, FYVE-CENT, KIAA0321zinc finger FYVE domain-containing protein 26, spastic paraplegia 15 (complicated, autosomal recessive), Spastizin, SPG15, zinc finger, FYVE domain containing 26

Gene Symbol

ZFYVE26

UniProt

EAW80952 (Human)

Additional ZFYVE26 Products

Product Documents for ZFYVE26 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ZFYVE26 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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