ZNF198 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56490

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Canine, Primate

Predicted:

Bovine (94%), Chicken (94%), Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all ZNF198 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 1250-1300 of human Zinc finger protein 198 was used as the immunogen.

Reactivity Notes

Xenopus proteins (76%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ZNF198 Antibody

Western Blot: ZNF198 Antibody [NB100-56490]

Western Blot: ZNF198 Antibody [NB100-56490]

Western Blot: ZNF198 Antibody [NB100-56490] - Analysis of ZNF198 in mouse skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide using this antibody at 0.1 ug/ml.
Immunohistochemistry-Paraffin: ZNF198 Antibody [NB100-56490]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NB100-56490]

Immunohistochemistry-Paraffin: ZNF198 Antibody [NB100-56490] - Analysis of human breast using this antibody at 10 ug/ml.

Applications for ZNF198 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

0.1-1 ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ZNF198

ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.

Alternate Names

FIMRAMPSCLL, Fused in myeloproliferative disorders protein, MYM, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198rearranged in an atypical myeloproliferative disorder, zinc finger, MYM-type 2, ZNF198zinc finger MYM-type protein 2

Entrez Gene IDs

7750 (Human); 76007 (Mouse); 305913 (Rat)

Gene Symbol

ZMYM2

UniProt

Q9UBW7 (Mouse)

Additional ZNF198 Products

Product Documents for ZNF198 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ZNF198 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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