Brorin/VWC2 Antibody Pair [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79385

Novus Biologicals, part of Bio-Techne
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

7.81-500 pg/ml (example only; lot dependent)

Sensitivity

7.81 pg/ml (example only; lot dependent)

Reactivity

Human

View all Brorin/VWC2 ELISA Kits »

Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human Brorin/VWC2.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for Brorin/VWC2 Antibody Pair [HRP]

Sandwich ELISA: Brorin/VWC2 Antibody Pair [HRP] [NBP2-79385] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for Brorin/VWC2 Antibody Pair [HRP]

  • Mouse Monoclonal Capture Antibody: (Catalog # NBP3-05797)
  • Mouse Monoclonal Detection Antibody (HRP-conjugated): (Catalog # NBP3-05796)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: Brorin/VWC2

Brorin (brain-specific chordin-like protein), also called VWC2, is an ~46 kDa glycoprotein that is a member of the Chordin family of secreted BMP regulators. The human Brorin cDNA encodes 325 amino acids (aa) including a 27 aa signal sequence and a 298 aa secreted mature protein with two VWFC domains. These domains contain a pattern of 10 cysteine residues that is conserved in other family members, with the remaining aa sequence sharing little identity. Human Brorin shares 90%, 91%, and 95% aa sequence identity with mouse, rat, and equine Brorin, respectively. It also shares aa identity with VWC2L (Brorin-like) of 37% overall and 62% within the VWFC domains. Brorin is predominantly expressed in embryonic and adult neural tissues in the mouse. Expression of Brorin mRNA is concentrated in neurons within the diencephalon and medulla oblongata but is not detected in the developing cerebral cortex. Brorin binds and antagonizes BMPs, interacting via the VWFC domains. It promotes neurogenesis in mouse neural precursors. Knockdown of Brorin in zebrafish embryos results in morphological abnormalities in the brain and eye.

Long Name

von Willebrand Factor A2 Domain

Alternate Names

Brain-specific chordin-like protein, VWC2

Gene Symbol

VWC2

Additional Brorin/VWC2 Products

Product Documents for Brorin/VWC2 Antibody Pair [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Brorin/VWC2 Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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