ErbB3/Her3 Antibody Pair [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79511

Novus Biologicals, part of Bio-Techne
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

18.75-1200 pg/ml (example only; lot dependent)

Sensitivity

18.75 pg/ml (example only; lot dependent)

Reactivity

Human

View all ErbB3/Her3 ELISA Kits »

Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human ErbB3/Her3.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for ErbB3/Her3 Antibody Pair [HRP]

Sandwich ELISA: ErbB3/Her3 Antibody Pair [HRP] [NBP2-79511] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for ErbB3/Her3 Antibody Pair [HRP]

  • Mouse Monoclonal Capture Antibody
  • Rabbit Monoclonal Detection Antibody (HRP-conjugated): (Catalog # NBP2-89333)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: ErbB3/Her3

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Long Name

Receptor Tyrosine Protein Kinase ErbB3

Alternate Names

HER3

Gene Symbol

ERBB3

Additional ErbB3/Her3 Products

Product Documents for ErbB3/Her3 Antibody Pair [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ErbB3/Her3 Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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