Human HMW Kininogen ELISA Kit (Colorimetric)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-60479

Novus Biologicals, part of Bio-Techne
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Key Product Details

Sample Type & Volume Required Per Well

Cell Culture, Urine, Saliva, Milk, CSF

Sensitivity

1.5 ng/ml (example only; lot dependent)

Assay Range

0.391 - 25 ng/mL (example only; lot dependent)

View all HMW Kininogen ELISA Kits »

Product Specifications

Assay Type

Sandwich ELISA

Kit Type

ELISA Kit (Colorimetric)

Reactivity

Human

Description

This assay employs a quantitative enzyme immunoassay technique that measures the specified antigen in samples.

Precision

Intra-Assay Precision (Precision within an assay) CV% < 4.90% (example only; lot dependent)

Inter-Assay Precision (Precision between assays) CV% < 7.20% (example only; lot dependent)

Recovery for Human HMW Kininogen ELISA Kit (Colorimetric)

Recovery

96.00% (example only; lot dependent)

Scientific Data Images for Human HMW Kininogen ELISA Kit (Colorimetric)

ELISA: Human HMW Kininogen ELISA Kit (Colorimetric) [NBP2-60479]

ELISA: Human HMW Kininogen ELISA Kit (Colorimetric) [NBP2-60479]

ELISA: Human HMW Kininogen ELISA Kit (Colorimetric) [NBP2-60479] - Standard curve.

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage is content dependent.

Background: HMW Kininogen

High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910)-kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond (Merkulov et al., 2008 [PubMed 18000168]).[supplied by OMIM]

Alternate Names

Alpha-2-thiol proteinase inhibitor, BDK, bradykinin, Fitzgerald factor, High molecular weight kininogen, kininogen, kininogen 1, kininogen-1, KNGHMWK, Williams-Fitzgerald-Flaujeac factor

Gene Symbol

KNG1

Additional HMW Kininogen Products

Product Documents for Human HMW Kininogen ELISA Kit (Colorimetric)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Human HMW Kininogen ELISA Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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