IL-18 BPa/IL18BP Antibody Pair [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79673

Novus Biologicals, part of Bio-Techne
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

46.88-3000 pg/ml (example only; lot dependent)

Sensitivity

46.88 pg/ml (example only; lot dependent)

Reactivity

Human

View all IL-18 BPa ELISA Kits »

Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human IL-18 BPa/IL18BP.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for IL-18 BPa/IL18BP Antibody Pair [HRP]

Sandwich ELISA: IL-18 BPa/IL18BP Antibody Pair [HRP] [NBP2-79673] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for IL-18 BPa/IL18BP Antibody Pair [HRP]

  • Mouse Monoclonal Capture Antibody
  • Rabbit Polyclonal Detection Antibody (HRP-conjugated)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: IL-18 BPa

IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).

Long Name

Interleukin 18 Binding Protein Isoform a

Alternate Names

IL18 BPa, IL18BP

Gene Symbol

IL18BP

Additional IL-18 BPa Products

Product Documents for IL-18 BPa/IL18BP Antibody Pair [HRP]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for IL-18 BPa/IL18BP Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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