APCDD1 293T Cell Transient Overexpression Lysate

Novus Biologicals, part of Bio-Techne | Catalog # H00147495-T01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species

Human

Applications

Western Blot

Product Summary for APCDD1 293T Cell Transient Overexpression Lysate

Quality control test: Transient overexpression cell lysate was tested with Anti-APCDD1 antibody by Western Blots. Plasmid: pCMV-APCDD1 full-length

Product Specifications

Specificity

APCDD1 293T Cell Transient Overexpression Lysate(Denatured)

Type

293T Cell Transient Overexpression

Protein State

Denatured

Scientific Data Images for APCDD1 293T Cell Transient Overexpression Lysate

APCDD1 transfected lysate.
Lane 1: APCDD1 transfected lysate (56.65 KDa) Lane 2: Non-transfected lysate.

Formulation, Preparation, and Storage

Formulation

1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)

Concentration

mg/ml

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -80C. Avoid freeze-thaw cycles.

Background: APCDD1

Adenomatosis polyposis coli down-regulated 1 protein (APCDD1), also known as DRAPC1, is a negative regulator of the Wnt signaling pathway. APCDD1 acts to inhibit Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin interaction. APCDD-1 is most strongly expressed in pancreas, heart, prostate, ovary, lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. APCDD1 is expressed in both the epidermal and dermal compartments of the hair follicle, and in the dermal papilla, the matrix, and the hair shaft. Mutations in the APCDD1 gene cause hypotrichosis simplex (HTS), a rare form of non-syndromic hereditary hypotrichosis characterized by progressive hairloss in early childhood. The APCDD1 protein has also been found overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1-mutated Wilms tumors.

APCDD1 antibodies may be useful for hair loss studies and research on certian cancers.

Long Name

APC Down Regulated 1

Alternate Names

APC Down Regulated 1, DRAPC1, HYPT1

Gene Symbol

APCDD1

Additional APCDD1 Products

Product Documents for APCDD1 293T Cell Transient Overexpression Lysate

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for APCDD1 293T Cell Transient Overexpression Lysate

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

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