BIRC8 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76669PEP

Novus Biologicals, part of Bio-Techne
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NBP1-76669PEP
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Key Product Details

Source

Synthetic

Conjugate

Unconjugated

Applications

Antibody Competition

View all BIRC8 Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 12 amino amino terminus of human ILP-2.

Source: Synthetic

(Accession #: NP_203127)

Purity

N/A

Application Notes

This peptide is useful as a blocking peptide for NBP1-76669.

For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NBP1-76669PEP
Formulation PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative 0.02% Sodium Azide
Concentration 0.2 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: BIRC8

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Long Name

Baculoviral IAP Repeat Containing 8

Alternate Names

ILP2, RNF136

Gene Symbol

BIRC8

Additional BIRC8 Products

Product Documents for BIRC8 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for BIRC8 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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