BTK [p Tyr223] Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-78295PEP

Novus Biologicals, part of Bio-Techne
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NBP1-78295PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all BTK Proteins and Enzymes »

Product Specifications

Description

A BTK antibody blocking peptide.

Modification

p Tyr223

Application Notes

This peptide is useful as a blocking peptide for NBP1-78295. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for NBP1-78295 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NBP1-78295PEP
Formulation Peptide dissolved in dH2O. Contains no BSA.
Preservative No Preservative
Concentration 1.0 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: BTK

Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. All members of the BTK/Tec family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.

Long Name

Bruton Agammaglobulinemia Tyrosine Kinase

Alternate Names

AGMX1, IMD1, PSCTK1, XLA

Gene Symbol

BTK

Additional BTK Products

Product Documents for BTK [p Tyr223] Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for BTK [p Tyr223] Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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