Recombinant Porcine CCL11/Eotaxin Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11053

Novus Biologicals, part of Bio-Techne
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NBP3-11053
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Key Product Details

Accession #

F1S162

Conjugate

Unconjugated

Applications

ELISA, Western Blot

View all CCL11/Eotaxin Proteins and Enzymes »

Product Specifications

Description

Recombinant Pig Eotaxin 1 is a recombinant protein corresponding to aa 24-97 of native pig Eotaxin 1.

Purity

>95%, by SDS-PAGE

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Porcine CCL11/Eotaxin Protein

ELISA: Recombinant Porcine CCL11/Eotaxin Protein [NBP3-11053]

ELISA: Recombinant Porcine CCL11/Eotaxin Protein [NBP3-11053]

ELISA: Recombinant CCL11/Eotaxin Protein [NBP3-11053] - Recombinant Pig Eotaxin-1 detected using Rabbit anti Pig Eotaxin-1 as the capture reagent and Rabbit anti Pig Eotaxin-1:Biotin as the detection reagent followed by Streptavidin:HRP.

Formulation, Preparation and Storage

NBP3-11053
Preparation Method Recombinant protein expressed in Pichia pastoris and purified by ion-exchange chromatography.
Formulation PBS
Preservative 10% Trehalose
Concentration Lyoph
Reconstitution Reconstitute with 20 uL sterile PBS containing 0.1% carrier protein. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: CCL11/Eotaxin

Eotaxin is a member of the CC chemokine family of inflammatory and immunoregulatory cytokines. Constitutive Eotaxin mRNA expression has been detected in multiple tissues, most often it appears to be induced by inflammatory cytokines such as IL-1, TNF-alpha and IFN-gamma in fibroblasts, endothelial and epithelial cells. Following allergen challenge Eotaxin mRNA has been shown to be rapidly up-regulated in airway epithelium an alveolar macrophages. Eotaxin expression has also been detected in smooth muscle cells, chondrocytes and eosinophils. Mouse Eotaxin activity is mediated by the mouse CC chemokine receptor CCR3, which, unlike human CCR3, can also be activated by mouse MIP-1alpha. Among CC chemokine familiy members, Eotaxin is functionally and structurally mostly related to the MCP/Eotaxin proteins. Mouse Eotaxin cDNA encodes a 97 amino acid residue precursor protein that is cleaved to generate the 74 aa residue mature protein. Mouse Eotaxin has been shown to be a potent chemoattractant for eosinophils during inflammation and allergic reactions and to be involved in the growth of myeloid cell progenitors and the differentiation of mast cells during embryonic development. A role in numerous eosinophil-associated gastrointestinals disorders as food allergy, parasitic infections, allergic colitis and inflammatory Bowel disease has been described.

Alternate Names

Eotaxin, CCL11, Eotaxin/CCL11

Gene Symbol

CCL11

UniProt

F1S162 (Porcine)

Additional CCL11/Eotaxin Products

Product Documents for Recombinant Porcine CCL11/Eotaxin Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Porcine CCL11/Eotaxin Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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