DEDD2 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56137PEP

Novus Biologicals, part of Bio-Techne
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NB100-56137PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all DEDD2 Proteins and Enzymes »

Product Specifications

Description

Application Notes

This peptide is useful as a blocking peptide for NB100-56137. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for NB100-56137 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NB100-56137PEP
Formulation Peptide dissolved in dH20. Contains no BSA.
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: DEDD2

Apoptosis and inflammation are important cellular processes that are highly regulated through specific protein-protein interactions (PPI). Proteins involved in these signaling cascades often carry PPI domains belonging to the death-domain superfamily (reviewed in Kohl A and MG Grutter, 2004). These PPI domains include the death effector domain (DED), the death domain (DD), the caspase activation and recruitment domain (CARD) and the pyrin domain (PYD). PPI domains are structurally related and comprised of a six alpha helical structure; within proteins PPI domains can be found in isolation or in combination with other domains. DEDD2/Flame-3 (DED containing DNA binding2) belongs to a family of single DED-containing proteins that is targeted to the nucleus (reviewed in Barnhart et al, 2003; Slvibst ry sl, 2003). Several DED-containing proteins are involved in the regulation of apoptosis through their interactions with DED-containing caspases. It is thought that DEDD2 and its closely related homologue DEDD may mediate cell death by binding to the DED-containing caspases -8 and -10, and targeting them to the nucleus following death receptor induced apoptosis. However, the function of DEDD2 and DEDD remain to be fully elucidated, and they may also have roles in cellular processes other than apoptosis. This antibody recognizes DEDD2/Flame-3; human DED2/Flame-3 is a 326 amino acid protein.

Alternate Names

death effector domain containing 2, death effector domain-containing DNA binding protein 2, DED-containing protein FLAME-3, DNA-binding death effector domain-containing protein 2, FADD-like apoptotic molecule 3, FLAME3, FLAME-3

Gene Symbol

DEDD2

Additional DEDD2 Products

Product Documents for DEDD2 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DEDD2 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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