Recombinant Human Dysbindin His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBC1-21266

Novus Biologicals, part of Bio-Techne
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NBC1-21266
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Key Product Details

Source

E. coli

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all Dysbindin Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-270 of Human Dysbindin

Source: E.coli

Amino Acid Sequence: MLSA HWEKKKTSLV ELQEQLQQLP ALIADLESMT ANLTHLEASF EEVENNLLHL EDLCGQCELE RCKHMQSQQ LENYKKNKRKE LETFKAELDA EHAQKVLEME HTQQMKLKER QKFFEEAFQQ DMEQYLSTGY LQIAERREPI GSMSSMEVNV DMLEQMDLMD ISDQEALDVF LNSGGEENTV LSPALGPESS TCQNEITLQV PNPSELRAKP PSSSSTCTDS ATRDISEGGE SPVVQSDEEE VQVDTALATS HTDREATPDG GEDSDS

Purity

>85%, by SDS-PAGE

Predicted Molecular Mass

34.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human Dysbindin His Protein

Recombinant Human Dysbindin His Protein

SDS-Page: Recombinant Human Dysbindin Protein [NBC1-21266] -

SDS-Page: Recombinant Human Dysbindin Protein [NBC1-21266] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Formulation, Preparation and Storage

NBC1-21266
Formulation 20 mM Tris-HCl buffer (pH 8.0), 100 mM NaCl, 0.5 MM DTT, 20% glycerol
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dysbindin

Dysbindin is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes. Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Alternate Names

DKFZp564K192, Dysbindin, Dysbindin-1, dystrobrevin binding protein 1, Dystrobrevin-binding protein 1, FLJ30031, Hermansky-Pudlak syndrome 7 protein, HPS7 protein, HPS7DBND, MGC20210, My031, SDY

Gene Symbol

DTNBP1

Additional Dysbindin Products

Product Documents for Recombinant Human Dysbindin His Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant Human Dysbindin His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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