Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein

Name: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein
Brand: Novus Biologicals
SKU: NBP3-14780

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14780

Submit a review

Product Datasheet / COA

100% Guarantee

Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Conjugate

Unconjugated

Applications

Microscopy, Functional Assay, SDS-PAGE, Western Blot

View all gamma-Synuclein Proteins and Enzymes »

Product Specifications

Description

A full length recombinant protein of Human gamma-Synuclein

Source: E. coli

Uniprot ID: O76070

Purity

>95%, by SDS-PAGE

Localization

Cytoskeleton, Centrosome, Spindle, Perinuclear Region

Protein / Peptide Type

Recombinant Protein

Scientific Data Images

In vitro assay: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780]

In vitro assay: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780] - Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in gamma synuclein fibrils. Increased fluorescence (correlated to gamma synuclein fibrillization) is seen when human gamma synuclein monomer is combined with human gamma synuclein PFFs (NBP3-14780).

Electron Microscopy: Recombinant Human gamma-Synuclein Active, Pre-formed Fibrils, (Type 1) Protein [NBP3-14780] - TEM of Active Human Recombinant gamma-Synuclein Protein Pre-formed Fibrils (Type 1) (NBP3-14780)

Formulation, Preparation and Storage

NBP3-14780

Preparation Method	Ion-exchange Purified
Formulation	PBS pH 7.4
Preservative	No Preservative
Concentration	Please see the vial label for concentration. If unlisted please contact technical services.
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -80C. Avoid freeze-thaw cycles.

Background: gamma-Synuclein

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. May be a centrosome-associated protein. Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family.

Alternate Names

BCSG1, PRSN, SNCG, Synoretin, Synuclein-gamma

Gene Symbol

SNCG

Additional gamma-Synuclein Products

Product Documents

Product Datasheets

Download Product Datasheets

COA

Product Specific Notices

Please note that the 200ug and 500ug sizes are sent in 2x100ug and 5x100ug vials, respectively

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Citations
Reviews