HOX11 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56424PEP

Novus Biologicals, part of Bio-Techne
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NB100-56424PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all HOX11 Proteins and Enzymes »

Product Specifications

Description

Application Notes

This peptide is useful as a blocking peptide for NB100-56424. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for NB100-56424 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NB100-56424PEP
Formulation Peptide dissolved in dH20. Contains no BSA.
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: HOX11

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Alternate Names

homeo box 11 (T-cell lymphoma 3-associated breakpoint), homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to DrosophilaNotch), Homeobox protein Hox-11, HOX11T-cell leukemia, homeobox 1, Proto-oncogene TCL-3, T-cell leukemia homeobox 1, T-cell leukemia homeobox protein 1, T-cell leukemia/lymphoma protein 3, TCL3MGC163402

Gene Symbol

TLX1

Additional HOX11 Products

Product Documents for HOX11 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HOX11 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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