Recombinant Human IL-1 RII Isoform 1 His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61984

Novus Biologicals, part of Bio-Techne
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Key Product Details

Source

Baculovirus

Tag

His

Conjugate

Unconjugated

Applications

Bioactivity, SDS-PAGE

View all IL-1 RII Proteins and Enzymes »

Product Specifications

Description

A Biologically active recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 14-343 of Human IL-1 RII

Source:Baculovirus

Amino Acid Sequence: FTLQPAAHTG AARSCRFRGR HYKREFRLEG EPVALRCPQV PYWLWASVSP RINLTWHKND SARTVPGEEE TRMWAQDGAL WLLPALQEDS GTYVCTTRNA SYCDKMSIEL RVFENTDAFL PFISYPQILT LSTSGVLVCP DLSEFTRDKT DVKIQWYKDS LLLDKDNEKF LSVRGTTHLL VHDVALEDAG YYRCVLTFAH EGQQYNITRS IELRIKKKKE ETIPVIISPL KTISASLGSR LTIPCKVFLG TGTPLTTMLW WTANDTHIES AYPGGRVTEG PRQEYSENNE NYIEVPLIFD PVTREDLHMD FKCVVHNTLS FQTLRTTVKE LEHHHHHH

Purity

>90%, by SDS-PAGE

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Predicted Molecular Mass

38.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

Measured by its ability to inhibit proliferation using D10.G4.1 mouse helper T cells. The ED50 range is less than or equal to 400 ng/ml with Human IL-1 beta/IL-1F2.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human IL-1 RII Isoform 1 His Protein

SDS-PAGE: Recombinant Human IL-1 RII Isoform 1 His Protein [NBP2-61984]

SDS-PAGE: Recombinant Human IL-1 RII Isoform 1 His Protein [NBP2-61984]

SDS-Page: Recombinant Human IL-1 RII Isoform 1 Protein [NBP2-61984] - 15% SDS-PAGE (3ug)

Formulation, Preparation and Storage

NBP2-61984
Formulation PBS (pH 7.4), 10% glycerol
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-1 RII

The protein encoded by the IL1R2 gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. (provided by RefSeq)

Long Name

Interleukin 1 Receptor II

Alternate Names

CD121b, IL-1 R beta, IL-1RII, IL1R2, IL1RII

Gene Symbol

IL1R2

Additional IL-1 RII Products

Product Documents for Recombinant Human IL-1 RII Isoform 1 His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human IL-1 RII Isoform 1 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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