Recombinant Bovine IL-1ra/IL-1F3/IL1RN Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-62451

Novus Biologicals, part of Bio-Techne
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Key Product Details

Source

Pichia pastoris

Accession #

O77482

Conjugate

Unconjugated

Applications

ELISA, Western Blot

View all IL-1ra/IL-1F3 Proteins and Enzymes »

Product Specifications

Description

Recombinant bovine interleukin-1RA.

Source:Pichia pastoris

Amino Acid Sequence:aa 24-174 of native bovine IL-1RA, UniProt O77482

Purity

>95%, by SDS-PAGE

Predicted Molecular Mass

17.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP2-62451
Preparation Method Recombinant protein expressed in Pichia pastoris and purified by ion-exchange chromatography.
Formulation PBS
Preservative 10% Trehalose
Concentration Lyoph
Reconstitution Reconstitute with 20 ul sterile PBS containing 0.1% carrier protein. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix vial after reconstitution.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: IL-1ra/IL-1F3

IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.

Long Name

Interleukin 1 Receptor Antagonist

Alternate Names

DIRA, ICIL-1ra, IL-1F3, IL-1ra3, IL-1RN, IL1ra, IL1RN, MVCD4

Gene Symbol

IL1RN

UniProt

O77482 (Bovine)

Additional IL-1ra/IL-1F3 Products

Product Documents for Recombinant Bovine IL-1ra/IL-1F3/IL1RN Protein

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Recombinant Bovine IL-1ra/IL-1F3/IL1RN Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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