Recombinant Bovine IL-21 Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-62453

Novus Biologicals, part of Bio-Techne
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NBP2-62453
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Key Product Details

Source

Pichia pastoris

Accession #

Q76LU5

Conjugate

Unconjugated

Applications

ELISA, Western Blot

View all IL-21 Proteins and Enzymes »

Product Specifications

Description

Recombinant bovine interleukin-21.

Source:Pichia pastoris

Amino Acid Sequence:aa 18-146 of native bovine IL-21,UniProt Q76LU5 aa 18-146 of native bovine IL-21.

Purity

>95%, by SDS-PAGE

Predicted Molecular Mass

15.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP2-62453
Preparation Method Recombinant protein expressed in Pichia pastoris and purified by ion-exchange chromatography.
Formulation PBS
Preservative 10% Trehalose
Concentration Lyoph
Reconstitution Reconstitute with 20 ul sterile PBS containing 0.1% carrier protein. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix vial after reconstitution.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: IL-21

IL-21 (Interleukin-21) is member of the family of cytokines that utilize the common gamma chain as a receptor subunit. This subunit is also a component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex of the common gamma chain and the IL-21-specific IL-21 R. IL-21 supports Tfh cell development, immunoglobulin affinity maturation, plasma cell differentiation, B cell memory responses, and the migration of dendritic cells to draining lymph nodes. It costimulates the activation, proliferation, and survival of CD8+ T cells and NKT cells and promotes Th17 cell polarization. It blocks the generation of regulatory T cells and their suppressive effects on CD4+ T cells. In addition, IL-21 suppresses cutaneous hypersensitivity reactions by limiting allergen-specific IgE production and mast cell degranulation.

Long Name

Interleukin 21

Alternate Names

CVID11, IL21, Za11

Gene Symbol

IL21

UniProt

Q76LU5 (Bovine)

Additional IL-21 Products

Product Documents for Recombinant Bovine IL-21 Protein

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Recombinant Bovine IL-21 Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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