Recombinant Human Annexin A2 Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9409-AN

R&D Systems, part of Bio-Techne
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9409-AN-050
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Key Product Details

Source

E. coli

Accession #

P07355-1

Conjugate

Unconjugated

View all Annexin A2 Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human Annexin A2 protein
Ser2-Asp339, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ser2

Predicted Molecular Mass

39 kDa

SDS-PAGE

38 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9409-AN
Formulation Lyophilized from a 0.2 μm filtered solution in PBS and DTT.
Reconstitution
Reconstitute at 500 μg/mL in PBS.

Reconstitution Buffer Available:
Size / Price
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Annexin A2

Annexin A2 (ANXA2), also known as Annexin II and Lipocortin II (LPC2), is a 39 kDa member of the Annexin family. Annexins are calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites. The C-terminal domain is comprised of four 60-70 aa annexin repeats which form a tightly packed disc known as the annexin domain. Members of the Annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways (1). Annexin A2 is heavily involved in membrane organization and traffic (2). Annexin A2 also functions as an autocrine factor to enhance osteoclast formation and bone resorption and is a major cellular substrate of the tyrosine kinase encoded by the SRC oncogene (3, 4). Human Annexin A2 shares 97% identity with mouse and rat Annexin A2.

References

  1. Gerke, V. et al. (2005) Nat. Rev. Mol. Cell Biol. 6:449.
  2. Hayes, M. et al. (2004). Traffic. 5:571.
  3. Siever, D. A., et al. (1997). ‎Int. J. Biochem. Cell Biol. 29:1219.
  4. Thiel, C. A. et al. (1992). J. Cell Sci. 103:733.

Alternate Names

ANX2L4, ANXA2, CAL1H, LIP2, Lipocortin-2, LPC2D, PAP-IV

Entrez Gene IDs

302 (Human); 12306 (Mouse); 56611 (Rat)

Gene Symbol

ANXA2

UniProt

P07355-1

Additional Annexin A2 Products

Product Documents for Recombinant Human Annexin A2 Protein, CF

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Product Specific Notices for Recombinant Human Annexin A2 Protein, CF

For research use only

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