Recombinant Human Annexin A4 Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9414-AN

R&D Systems, part of Bio-Techne
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9414-AN-050
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Key Product Details

Source

E. coli

Accession #

NP_001144

Conjugate

Unconjugated

View all Annexin A4 Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human Annexin A4 protein
Ala2-Asp321, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Ala2

Predicted Molecular Mass

37 kDa

SDS-PAGE

35 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9414-AN
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 500 μg/mL in PBS.

Reconstitution Buffer Available:
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Annexin A4

Annexin A4 (ANXA4), also known as Lipocortin IV, placental anticoagulant protein II, and zymogen granule membrane-associated protein of 36 kDa (ZAP36), is a member of the Annexin protein family. Annexins are calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites. The C-terminal domain is comprised of four 60-70 aa annexin repeats which form a tightly packed disc known as the annexin domain. Members of the Annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. (1) Annexin A4 regulates the transcription from RNA polymerase II promoter (2). The level of Annexin A4 increases in cytoplasm during apoptosis (3). Human Annexin A4 shares 92% aa sequence identity with mouse and rat Annexin A4.

References

  1. Gerke, V. et al. (2005) Nat. Rev. Mol. Cell Biol. 6:449.
  2. Jeon, Y. J. et al. (2010). Cellular and molecular life sciences, 67:2271.
  3. Gerner, C. et al. (2000). J. Biol. Chem. 275:39018

Alternate Names

AIV, Annexin IV, ANX4, ANXA4, Lipocortin IV, PIG28, ZAP36

Entrez Gene IDs

307 (Human); 11746 (Mouse); 79124 (Rat)

Gene Symbol

ANXA4

UniProt

NP_001144

Additional Annexin A4 Products

Product Documents for Recombinant Human Annexin A4 Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human Annexin A4 Protein, CF

For research use only

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