Recombinant Human DDB1 Protein, CF

R&D Systems, part of Bio-Techne | Catalog # E3-501

R&D Systems, part of Bio-Techne
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E3-501-050
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Key Product Details

Source

Sf 21 (baculovirus)

Accession #

Q16531.1

Conjugate

Unconjugated

Applications

Bioactivity

View all DDB1 Proteins and Enzymes »

Product Specifications

Source

Spodoptera frugiperda, Sf 21 (baculovirus)-derived human DDB1 protein
Met1 - His1140

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Predicted Molecular Mass

127 kDa

Formulation, Preparation and Storage

E3-501
Formulation Supplied as a solution in HEPES, NaCl, DTT and Glycerol.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.

Background: DDB1

DNA damage-binding protein 1 (DDB1) is a component of the UV-damaged DNA binding (UV-DDB) complex which minimally consists of DDB1 and DDB2.  At 1,140 amino acids in length and a predicted molecular weight of 127 kDa, human DDB1 is 99% identical to both its mouse and rat orthologues.  DDB1 is also a component of DCX (DDB1-CUL4-X-box) E3 Ubiquitin Ligase complexes where it serves to associate the Cullin-4 subunit to substrate recognition subunits such as Cereblon (CRBN), and various DCAF (DDB1-CUL4 Associate Factor) proteins.  

References

  1. Fischer E.S. et al. (2014) Nature 512: 49.
  2. He Y.J., et al. (2006) Genes Dev.  20: 2949.
  3. Ito T., et al. (2010) Science 327: 1345.
  4. Wang H., et al. (2006) Mol. Cell  22: 383.

Long Name

Damage-specific DNA Binding Protein 1

Alternate Names

DDB p127 Subunit, DDBA, UV-DDB 1, XPCE

Entrez Gene IDs

1642 (Human); 13194 (Mouse); 64470 (Rat)

Gene Symbol

DDB1

UniProt

Q16531.1

Additional DDB1 Products

Product Documents for Recombinant Human DDB1 Protein, CF

Product Datasheets

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Product Specific Notices for Recombinant Human DDB1 Protein, CF

For research use only

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