Recombinant Human GPR37 Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9609-GP

R&D Systems, part of Bio-Techne
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9609-GP-050
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Key Product Details

Source

CHO

Accession #

O15354

Conjugate

Unconjugated

View all GPR37 Proteins and Enzymes »

Product Specifications

Source

Chinese Hamster Ovary cell line, CHO-derived human GPR37 protein
Leu28-Met265, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu28

Predicted Molecular Mass

26 kDa

SDS-PAGE

37-53 kDa, reducing conditions

Activity

Bioassay data are not available.

Formulation, Preparation and Storage

9609-GP
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute at 250 μg/mL in PBS.

Reconstitution Buffer Available:
Size / Price
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Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GPR37

GPR37 (G-protein coupled receptor 37), also called ETBR-LP-1 (endothelin B receptor-like protein 1) or PAELR (Parkin-associated endothelin receptor-like receptor) is a 587 aa, 7-transmembrane receptor for the neuroprotective and glioprotective factor prosaposin  (1, 4).  It is mainly expressed in neuronal cells, particularly in cerebellar Purkinje cells and the hippocampus (2). It is a substrate of the E3 ubiquitin ligase, parkin, which is up-regulated during endoplasmic reticulum stress (3). In a juvenile form of Parkinson's disease, GPR37 accumulates, contributing to stress-induced neuronal cell death (2). The  extracelluar domains (aa 27-265) of human and mouse GPR37 share 68% aa identity.

References

  1. Marazziti, D. et al. (1997) Genomics, 45:68.
  2. Donohue, P.J. et al. (1998) Brain Res Mol Brain Res. 54:152.
  3. Omura, T. et al. (2006) J Neurochem. 99:1456.
  4. Meyer, R.C. et al. (2013) Proc. Natl. Acad. Sci. U. S. A. 110: 9529
 

Long Name

G Protein-coupled Receptor 37

Alternate Names

ETBR-LP-1, PAELR

Entrez Gene IDs

2861 (Human); 14763 (Mouse); 117549 (Rat)

Gene Symbol

GPR37

UniProt

O15354

Additional GPR37 Products

Product Documents for Recombinant Human GPR37 Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human GPR37 Protein, CF

For research use only

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