Recombinant Human TSPAN14-LEL Fc Chimera Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 11552-TS

R&D Systems, part of Bio-Techne
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11552-TS-100
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Key Product Details

Source

HEK293

Structure / Form

Disulfide linked homodimer

Conjugate

Unconjugated

Applications

Bioactivity

View all TSPAN14 Proteins and Enzymes »

Product Specifications

Source

Human embryonic kidney cell, HEK293-derived human TSPAN14 protein
MD Human IgG1
(Pro100-Lys330)
 IEGR Human TSPAN14-LEL
(LEU114-Asn232)
Accession # Q8NG11.1
N-terminus C-terminus

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Met

Predicted Molecular Mass

40 kDa

SDS-PAGE

43-54 kDa, under reducing conditions

Activity

Bioassay data are not available.

Scientific Data Images for Recombinant Human TSPAN14-LEL Fc Chimera Protein, CF

Recombinant Human TSPAN14-LEL Fc Chimera Protein SDS-PAGE.

2 μg/lane of Recombinant Human TSPAN14-LEL Fc Chimera Protein (Catalog # 11552-TS) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 43-54 kDa and 90-110 kDa, respectively.

Formulation, Preparation and Storage

11552-TS
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TSPAN14

Tetraspanin 14, or TSPAN14, belongs to a superfamily of proteins that is characterized by four transmembrane domains, three intracellular domains and two extracellular loops: a small extracellular loop (SEL) and a large extracellular loop (LEL). The extracellular loops form molecular webs that bring together cell surface proteins, facilitating the formation of stable and functional signalling complexes. Tetraspanins form microdomains on the plasma membrane that mediate diverse biological processes including adhesion, cell fusion, immune response, and tumor development (1-4). Human TSPAN14 consists of 270 amino acids, with the LEL region spanning residues 114-232. Within the LEL, human TSPAN14 shares 98% aa sequence identity with mouse and rat TSPAN14-LEL.

References

  1. Charrin, S. et al. (2014) J. Cell Sci. 127:3641.
  2. Yang, J. et al. (2024) Cell. 13:193.
  3. Hemler, M.E. (2005) Nat. Rev. Mol. Cell Biol.6:801.
  4. Kim, T-K. et al. (2015) Biochem. Biophys. Res. Commun. 468:774.

Long Name

Tetraspanin 14

Alternate Names

DC-TM4F2, Tetraspanin-14, TM4SF14

Entrez Gene IDs

81619 (Human); 52588 (Mouse); 306324 (Rat)

Gene Symbol

TSPAN14

Additional TSPAN14 Products

Product Documents for Recombinant Human TSPAN14-LEL Fc Chimera Protein, CF

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Human TSPAN14-LEL Fc Chimera Protein, CF

For research use only

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