Recombinant Mouse IL-4I1 Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 5576-AO
Key Product Details
Product Specifications
Source
Chinese Hamster Ovary cell line, CHO-derived mouse IL-4I1 protein
Leu21-Ser630, with a C-terminal 6-His tag
Leu21-Ser630, with a C-terminal 6-His tag
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
Leu21
Predicted Molecular Mass
69 kDa
SDS-PAGE
86 kDa, reducing conditions
Activity
Measured by its ability to produce hydrogen peroxide during the oxidation of phenylalanine.
The specific activity is >100 pmol/min/μg, as measured under the described conditions.
The specific activity is >100 pmol/min/μg, as measured under the described conditions.
Formulation, Preparation and Storage
5576-AO
| Formulation | Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol. |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: IL-4I1
Interleukin four-induced gene 1 (IL-4I1) was first identified in mouse B cells as part of the response to IL-4, a key regulator of the immune response (1). Later, the enzyme was shown to be a member of the flavin-containing amino acid oxidase family and closely related to L-amino acid oxidases (2, 3). Enzymological characterization reveals that IL-4I1 has L-amino acid oxidase activity with preference toward aromatic amino acids (4). Its limited expression in immune tissues, dendritic cells, and macrophages indicates that it may play an important function in the immune system (5, 6).
References
- Chu, C.C. and W.E. Paul (1997) Proc. Natl. Acad. Sci. USA 94:2507.
- Raibekas, A.A. and V. Massey (1998) Biochem. Biophys. Res. Comm. 248:476.
- Chavan, S.S. et al. (2002) Biochim. Biophys. Acta 1576:70.
- Mason, J.M. et al. (2004) J. Immunol. 173:4561.
- Copie-Berman, C. et al. (2003) Blood 101:2756.
- Bolland, M.-L. et al. (2007) Blood 110:220.
Long Name
Interleukin 4-induced Protein-1
Alternate Names
FIG1, IL4I1
Gene Symbol
IL4I1
UniProt
Additional IL-4I1 Products
Product Documents for Recombinant Mouse IL-4I1 Protein, CF
Product Specific Notices for Recombinant Mouse IL-4I1 Protein, CF
For research use only
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