Recombinant Human RelA/NFkB p65 Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24987

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP2-24987-5ug
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Source

E. coli

Conjugate

Unconjugated

Applications

ELISA

View all RelA/NFkB p65 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein corresponding to amino acids 1 - 537 of RELA. This represents a C-terminal truncation of 14 amino acids; the full-length human p65 NF-kB protein is 551 amino acids.

Purity

Immunogen affinity purified

Activity

The biological activity of this protein or its ability to bind to DNA has not been established. The NF-kB p65 protein is routinely used as a standard in p65 ELISA Kit (NBP2-29661).

Applications

ELISA (1:100-1:2000)

Application Notes

The purity is greater than 98.0%

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human RelA/NFkB p65 Protein

ELISA: Recombinant Human RelA/NFkB p65 Protein [NBP2-24987]

ELISA: Recombinant Human RelA/NFkB p65 Protein [NBP2-24987]

ELISA: Recombinant Human RelA/NFkB p65 Protein [NBP2-24987] - Standard curve using the internal RelA standard.

Formulation, Preparation and Storage

NBP2-24987
Formulation Tris-HCl, 0.2 M NaCl, 2 mM MgCl2, 0.2 mM EDTA, 1M DTT.
Concentration 0.5 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: RelA/NFkB p65

Nuclear factor B (NF-B) encompasses an important family of inducible transcriptional activators that regulate a wide variety of cellular and viral genes. The family members include p50, p52, p65 (RelA), c-Rel, and RelB. The Nf-kB p65 subunit, similar to two others in the B family, RelB and c-Rel, contains two transactivation domains in the C-terminal region of the protein. Association with inhibitory proteins of the I B family, retains NF- B in the cytoplasm. Degradation of IB proteins exposes the nuclear localization sequence (NLS), leading to nuclear translocation and subsequent binding of NF-B to DNA. In addition to the nuclear translocation and DNA binding, Nf-kB's transcriptional activity is also regulated by coactivators and corepressors in the nucleus. Interaction of p65 with coactivators; CREB-binding protein and p300, increases its transcriptional activity.

Long Name

v-rel Reticuloendotheliosis Viral Oncogene Homolog A

Alternate Names

NFkB p65, NFKB3, p65RelA

Gene Symbol

RELA

Additional RelA/NFkB p65 Products

Product Documents for Recombinant Human RelA/NFkB p65 Protein

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Recombinant Human RelA/NFkB p65 Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.