Separase Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # BC110-55295PEP

Novus Biologicals, part of Bio-Techne
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BC110-55295PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all Separase Proteins and Enzymes »

Product Specifications

Description

A ESPL1 antibody blocking peptide.

Application Notes

This peptide is useful as a blocking peptide for BC110-55295. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for BC110-55295 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

BC110-55295PEP
Formulation Peptide dissolved in dH2O. Contains no BSA.
Preservative No Preservative
Concentration 1.0 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: Separase

Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase, but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers. Separase antibodies can be used as a specific marker for centrosomes of mitotic cells. The staining of separase in centrosomes can be detected from prophase of mitosis up until anaphase.

Alternate Names

ESPL1, PRCE

Gene Symbol

ESPL1

Additional Separase Products

Product Documents for Separase Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Separase Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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