SESN2 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-44989PEP

Novus Biologicals, part of Bio-Techne
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Key Product Details

Source

Synthetic

Conjugate

Unconjugated

Applications

Antibody Competition

View all SESN2 Proteins and Enzymes »

Product Specifications

Description

A SESN2 antibody blocking peptide corresponding to amino acids 1 - 55 of human SESN2

GenBank Accession #: AAM922611

Source: Synthetic

Purity

>85%, by HPLC

Application Notes

This peptide is useful as a blocking peptide for NBP1-44989.

For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Scientific Data Images for SESN2 Antibody Blocking Peptide

Western Blot: SESN2 Antibody Blocking Peptide [NBP1-44989PEP]

Western Blot: SESN2 Antibody Blocking Peptide [NBP1-44989PEP]

Western Blot: SESN2 Blocking Peptide [NBP1-44989PEP] - Western Blot of SESN2 Peptide with SESN2 Antibody in DiluObuffer.

Formulation, Preparation and Storage

NBP1-44989PEP
Formulation Sodium Bicarbonate buffer, pH 8.00 containing up to 10% DMSO
Concentration 2.5 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: SESN2

Sestrin 2(SESN2), located at human chromosome 1p35.3, belongs to the sestrin family of proteins. These proteins are cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense (1). This family of proteins is only present in multicellular organisms ranging from nematodes to mammals. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes (2). Peroxiredoxins are the enzymes that metabolize peroxides. Expression of these proteins is regulated by p53, a tumor suppressor protein (3). Recently it was reported that sestrin 2 is not a sulfinic peroxiredoxin reductase (4). Sestrin 2 is implicated in the regulation of cell growth and survival, in cellular responses to different stress conditions, and also acts as a positive regulator of autophagy (5). Depletion of sestrin 2 in human cancer cells reduced the level of autophagy when autophagy was induced in these cells (5). Similar to sestrin 1, sestrin 2 negatively regulates the activity of mammalian target of rapamycin (mTOR), a positive regulator of cell growth (6). Sestrin 2 may be a promising target in the treatment of chronic obstructive pulmonary disease (COPD). It was reported that mutational inactivation of sestrin 2 induced TGF-Beta signaling and partially reduced the emphysema phenotype in mice model of COPD (7). Sestrin 2 might also be a key target in the treatment of cancer. It was shown to activate AMPK and repress mTORC1 signaling. AMPK is an essential mediator of LKB1 tumor suppressor and it is down-regulated in cancer cells (8). Sestrin 2 is approximately a 57.6kDa protein based on the amino acid predicted MW of 57kDa (480 amino acids).

Alternate Names

DKFZp761M0212, DKFZp761M02121, Hi95, HI95sestrin-2, SES2, SEST2hypoxia induced gene 95, sestrin 2

Gene Symbol

SESN2

Additional SESN2 Products

Product Documents for SESN2 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SESN2 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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