Recombinant Human STAT1 His (C-Term) Protein

Name: Recombinant Human STAT1 His (C-Term) Protein
Brand: Novus Biologicals
SKU: NBP3-18204

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18204

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

Sf 9 (baculovirus)

Tag

His (C-Term)

Conjugate

Unconjugated

Applications

SDS-PAGE

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Product Specifications

Description

A recombinant protein with a C-terminal 6xHis tag corresponding to the amino acids Met1-Val712 of Human STAT1.

Source: Sf 9 (baculovirus)

(Accession #: NP_644671.1)

Store at -20C to -80C long term. After reconstitution, the product is stable at -20C for 3 months, and 2-8C for up to 1 week.

Purity

>92%, by SDS-PAGE

Endotoxin Level

< 1.0 EU/ug of the protein by LAL method

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human STAT1 His (C-Term) Protein

SDS-PAGE: Recombinant Human STAT1 His (C-Term) Protein [NBP3-18204]

SDS-Page: Recombinant Human STAT1 His (C-Term) Protein [NBP3-18204] - Recombinant Human STAT1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 85-100 kDa.

Formulation, Preparation and Storage

NBP3-18204

Formulation	Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4
Concentration	Lyoph
Reconstitution	Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C.

Background: STAT1

STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-a, IFN-b, IFN-g and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1a and the 84 kDa STAT1b which are encoded by the same gene with splicing variant.

Long Name

Signal Transducer and Activator of Transcription 1

Alternate Names

CANDF7, ISGF-3, STAT91

Gene Symbol

STAT1

Additional STAT1 Products

Product Documents for Recombinant Human STAT1 His (C-Term) Protein

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COA

Product Specific Notices for Recombinant Human STAT1 His (C-Term) Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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