Thyroglobulin Native Protein

Name: Thyroglobulin Native Protein
Brand: Novus Biologicals
SKU: NBP2-62537

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-62537

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Product Datasheet / COA

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Product Specifications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

Human serum

Accession #

P01266

Conjugate

Unconjugated

Applications

ELISA

View all Thyroglobulin Proteins and Enzymes »

Product Specifications

Description

Native human thyroglobulin.

Source:Human thyroid glands Amino Acid Sequence:UniProt P01266

Product is purified by size exclusion chromatography (>96% purity)

Purity

Size Exclusion Chromatography

Predicted Molecular Mass

660 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Native Protein

Formulation, Preparation and Storage

NBP2-62537

Formulation	PBS
Preservative	No Preservative
Concentration	1 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C. Avoid freeze-thaw cycles.

Background: Thyroglobulin

Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47.

Alternate Names

AITD3, cog, TDH3, Tg, TGN

Gene Symbol

UniProt