Thyroglobulin Native Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-62538

Novus Biologicals, part of Bio-Techne
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Key Product Details

Accession #

P01267

Conjugate

Unconjugated

Applications

ELISA

View all Thyroglobulin Proteins and Enzymes »

Product Specifications

Description

Native bovine thyroglobulin.

Source:Bovine thyroid glands

Amino Acid Sequence:UniProt P01267

Protein / Peptide Type

Native Protein

Formulation, Preparation and Storage

NBP2-62538
Formulation PBS
Preservative No Preservative
Concentration 5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: Thyroglobulin

Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47.

Alternate Names

AITD3, cog, TDH3, Tg, TGN

Gene Symbol

TG

UniProt

P01267 (Bovine)

Additional Thyroglobulin Products

Product Documents for Thyroglobulin Native Protein

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Product Specific Notices for Thyroglobulin Native Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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