Recombinant Human TRAILR2/TNFRSF10B Isoform 1 hIgG-His Protein

Name: Recombinant Human TRAILR2/TNFRSF10B Isoform 1 hIgG-His Protein
Brand: Novus Biologicals
SKU: NBP2-61983

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61983

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Technical Data
Citations & Reviews

Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

Baculovirus

Tag

hIgG-His

Conjugate

Unconjugated

Applications

Bioactivity, SDS-PAGE

View all TRAIL R2/TNFRSF10B Proteins and Enzymes »

Product Specifications

Description

A Biologically active recombinant protein with a C-Terminal hIgG-His-tag and corresponding to the amino acids 56-210 of Human TRAIL R2/TNFRSF10B

Source:Baculovirus

Amino Acid Sequence: ITQQDLAPQQ RAAPQQKRSS PSEGLCPPGH HISEDGRDCI SCKYGQDYST HWNDLLFCLR CTRCDSGEVE LSPCTTTRNT VCQCEEGTFR EEDSPEMCRK CRTGCPRGMV KVGDCTPWSD IECVHKESGT KHSGEVPAVE ETVTSSPGTP ASPCSLEPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGKHH HHHH

Purity

>90%, by SDS-PAGE

Endotoxin Level

< 1.0 EU per 1ug of protein (determined by LAL method)

Predicted Molecular Mass

43.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

Measured by its ability to inhibit cytotoxicity using Jurkat human acute T cell leukemia cells. The ED50 range is less than or equal to 5 ng/ml with Human TRAIL.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human TRAILR2/TNFRSF10B Isoform 1 hIgG-His Protein

SDS-PAGE: Recombinant Human TRAILR2/TNFRSF10B Isoform 1 hIgG-His Protein [NBP2-61983]

SDS-Page: Recombinant Human TRAIL R2/TNFRSF10B Isoform 1 Protein [NBP2-61983] - 15% SDS-PAGE (3ug)

Formulation, Preparation and Storage

NBP2-61983

Formulation	PBS (pH 7.4), 10% glycerol
Preservative	No Preservative
Concentration	1 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAIL R2/TNFRSF10B

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Long Name

TRAIL Receptor 2

Alternate Names

CD262, DR5, TNFRSF10B, TRAILR2

Gene Symbol

TNFRSF10B

Additional TRAIL R2/TNFRSF10B Products

Product Documents for Recombinant Human TRAILR2/TNFRSF10B Isoform 1 hIgG-His Protein

Product Datasheets

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COA

Product Specific Notices for Recombinant Human TRAILR2/TNFRSF10B Isoform 1 hIgG-His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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