WNK4 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NB600-284PEP

Novus Biologicals, part of Bio-Techne
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NB600-284PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all WNK4 Proteins and Enzymes »

Product Specifications

Description

A WNK4 antibody blocking peptide.

Application Notes

This peptide is useful as a blocking peptide for NB600-284. For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NB600-284PEP
Formulation PBS
Concentration 1.0 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: WNK4

WNK4 (protein kinase with no lysine 4) is a novel serine/threonine kinase which plays critical role in regulation of electrolyte homeostasis, signal transduction, survival and proliferation. WNK4 is highly expressed in kidney, colon and skin where it forms a part of tight junction complex and interacts with/activate several proteins including SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5, NEDD4L and TRPV6. It control SLC12A3 (thiazide-sensitive Na-Cl cotransporter) activity by phosphorylation process that prevents membrane trafficking of SLC12A3. WNK4 inhibits KCNJ1 (renal K+ channel) via a kinase-independent action leading to induction of protein clearance from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that controls NaCl reabsorption and K+ secretion for maintaining integrated homeostasis. Autophosphorylation of Ser-335 is essential for WNK4's activity whereas phosphorylation of Ser-331 also increase its activity. Mutations of WNK4 can cause pseudohypoaldosteronism type alpha (PHA alpha), an autosomal dominant disease characterized by hyperkalemia, metabolic acidosis and hypertension.

Alternate Names

EC 2.7.11, EC 2.7.11.1, PHA2B, PRKWNK4protein kinase, lysine deficient 4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4, serine/threonine-protein kinase WNK4, WNK lysine deficient protein kinase 4

Gene Symbol

WNK4

Additional WNK4 Products

Product Documents for WNK4 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for WNK4 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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