2-Iodomelatonin

Name: 2-Iodomelatonin
Brand: Tocris Bioscience
SKU: 0737

Tocris Bioscience, part of Bio-Techne | Catalog # 0737

Citations (10)

COA / SDS

High affinity melatonin agonist

Key Product Details

Description:	High affinity melatonin agonist
Chemical Name:	N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	358.18

View Full Technical Details for 2-Iodomelatonin

Technical Data
Citations

Biological Activity for 2-Iodomelatonin

2-Iodomelatonin is a potent melatonin agonist (pK_i values are 10.55 and 9.87 at human recombinant MT₁ and MT₂ receptors respectively). 2-[¹²⁵I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Technical Data for 2-Iodomelatonin

M. Wt	358.18
Formula	C₁₃H₁₅IN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	93515-00-5
PubChem ID	115348
InChi Key	FJDDSMSDZHURBJ-UHFFFAOYSA-N
Smiles	COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Iodomelatonin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.82	100
	ethanol	35.82	100

Preparing Stock Solutions for 2-Iodomelatonin

The following data is based on the product molecular weight 358.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.96 mL	27.92 mL
5 mM	0.56 mL	2.79 mL	5.58 mL
10 mM	0.28 mL	1.40 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for 2-Iodomelatonin

References are publications that support the biological activity of the product.

Dubocovich and Takahashi Use of 2-[¹²⁵l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 1987 PMID: 3035559
Suiciak Quantitative pharmacological analysis of 2-[¹²⁵l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 1991 PMID: 1652626
Browning Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 2000 PMID: 10696085