2-TEDC

Name: 2-TEDC
Brand: Tocris Bioscience
SKU: 0645

Tocris Bioscience, part of Bio-Techne | Catalog # 0645

Citations (7)

COA / SDS

5-, 12-, 15-Lipoxygenase inhibitor

Key Product Details

Description:	5-, 12-, 15-Lipoxygenase inhibitor
Chemical Name:	2-(1-Thienyl)ethyl 3,4-dihydroxybenzylidenecyanoacetate
Purity:	≥99% (HPLC)
Molecular Weight:	315.34

View Full Technical Details for 2-TEDC

Technical Data
Citations

Biological Activity for 2-TEDC

2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase (IC₅₀ values are 0.09, 0.013 and 0.5 μM respectively).

Technical Data for 2-TEDC

M. Wt	315.34
Formula	C₁₆H₁₃NO₄S
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	132465-10-2
PubChem ID	6069552
InChi Key	KCGLTUBCAGZLHP-XYOKQWHBSA-N
Smiles	OC1=C(O)C=C(\C=C(/C#N)C(=O)OCCC2=CC=CS2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-TEDC

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	25

Preparing Stock Solutions for 2-TEDC

The following data is based on the product molecular weight 315.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL
10 mM	0.32 mL	1.59 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for 2-TEDC

References are publications that support the biological activity of the product.

Cho Novel caffeic acid derivatives - extremely potent inhibitors of 12-lipoxygenase. J.Med.Chem. 1991 PMID: 2016727