3-AP

Name: 3-AP
Brand: Tocris Bioscience
SKU: 5962

Tocris Bioscience, part of Bio-Techne | Catalog # 5962

Citations (1)

COA / SDS

Ribonucleotide reductase inhibitor; also an iron chelator

Key Product Details

Description:	Ribonucleotide reductase inhibitor; also an iron chelator
Alternative Names:	3-aminopyridine-2-carboxaldehyde thiosemicarbazone
Chemical Name:	2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
Purity:	≥98% (HPLC)
Molecular Weight:	195.24

View Full Technical Details for 3-AP

Technical Data
Citations

Biological Activity for 3-AP

3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

Technical Data for 3-AP

M. Wt	195.24
Formula	C₇H₉N₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	143621-35-6
PubChem ID	9571836
InChi Key	XMYKNCNAZKMVQN-NYYWCZLTSA-N
Smiles	NC(N/N=C/C1=C(C=CC=N1)N)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3-AP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	19.52	100

Preparing Stock Solutions for 3-AP

The following data is based on the product molecular weight 195.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.61 mL	51.22 mL
5 mM	1.02 mL	5.12 mL	10.24 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.10 mL	0.51 mL	1.02 mL

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Reconstitution Calculator

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References for 3-AP

References are publications that support the biological activity of the product.

Finch Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 1999 PMID: 10470363
Liu Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 1992 PMID: 1433178
Arid Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 2015 PMID: 24486217