3PO

Name: 3PO
Brand: Tocris Bioscience
SKU: 5121

Tocris Bioscience, part of Bio-Techne | Catalog # 5121

Citations (3)

COA / SDS

PFKFB3 inhibitor

Key Product Details

Chemical Name:	3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
Purity:	≥99%

View Full Technical Details for 3PO

Technical Data
Citations

Biological Activity for 3PO

3PO is originally reported to inhibit PFKFB3 (IC₅₀ = 25 μM). More recent reports failed to demonstrate activity in a PFKFB3 kinase assay. Reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G₂/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.

Technical Data for 3PO

Formula	C₁₃H₁₀N₂O
Storage	Store at -20°C
Purity	≥99%
CAS Number	13309-08-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3PO

Solubility

Soluble Soluble to 100 mM in DMSO

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 3PO

References are publications that support the biological activity of the product.

Boyd et al. Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem., 2015;58:3611 PMID: 25849762
Schoors et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab., 2014;19:37 PMID: 24332967
Clem et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther., 2008;7:110 PMID: 18202014

3PO

Tocris Bioscience, part of Bio-Techne | Catalog # 5121

Key Product Details

Biological Activity for 3PO

Technical Data for 3PO

Solubility for 3PO

Dilution Calculator

Reconstitution Calculator

References for 3PO

Product Documents for 3PO

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected