4μ8C

Name: 4μ8C
Brand: Tocris Bioscience
SKU: 4479

Tocris Bioscience, part of Bio-Techne | Catalog # 4479

Citations (12)

COA / SDS

Inhibits IRE1α endoribonuclease activity

Key Product Details

Description:	Inhibits IRE1α endoribonuclease activity
Chemical Name:	7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Purity:	≥98%
Molecular Weight:	204.18

View Full Technical Details for 4μ8C

Technical Data
Citations

Biological Activity for 4μ8C

4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Compound Libraries for 4μ8C

4μ8C is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4μ8C

M. Wt	204.18
Formula	C₁₁H₈O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	14003-96-4
PubChem ID	12934390
InChi Key	RTHHSXOVIJWFQP-UHFFFAOYSA-N
Smiles	CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4μ8C

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.42	100

Preparing Stock Solutions for 4μ8C

The following data is based on the product molecular weight 204.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.90 mL	24.49 mL	48.98 mL
5 mM	0.98 mL	4.90 mL	9.80 mL
10 mM	0.49 mL	2.45 mL	4.90 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

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Reconstitution Calculator

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References for 4μ8C

References are publications that support the biological activity of the product.

Cross The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 2012 PMID: 22315414