(±)-5'-Chloro-5'-deoxy-ENBA

Name: (±)-5'-Chloro-5'-deoxy-ENBA
Brand: Tocris Bioscience
SKU: 3576
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3576

(1)

Citations (4)

COA / SDS

Highly selective A1 agonist

Key Product Details

Description:	Highly selective A₁ agonist
Chemical Name:	N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine
Purity:	≥98% (HPLC)
Molecular Weight:	379.84

View Full Technical Details for (±)-5'-Chloro-5'-deoxy-ENBA

Technical Data
Citations / Reviews (1)

Biological Activity for (±)-5'-Chloro-5'-deoxy-ENBA

(±)-5'-Chloro-5'-deoxy-ENBA is a highly selective adenosine A₁ receptor agonist (K_i values are 0.51, 1290, 1340 and 2740 nM at A₁, A₃, A_2A and A_2B receptors respectively). Reverses formalin-induced nocifensive behavior in mice; antinociceptive.

Compound Libraries for (±)-5'-Chloro-5'-deoxy-ENBA

(±)-5'-Chloro-5'-deoxy-ENBA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (±)-5'-Chloro-5'-deoxy-ENBA

M. Wt	379.84
Formula	C₁₇H₂₂ClN₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	103626-26-2
PubChem ID	42636897
InChi Key	PVJGDYDNVNCGBT-STHLEMNDSA-N
Smiles	O[C@@H]1[C@H](O)[C@@H](CCl)O[C@H]1N(C=N3)C2=C3C(NC4C5CCC(C5)C4)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-5'-Chloro-5'-deoxy-ENBA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.98	100
	ethanol	37.98	100

Preparing Stock Solutions for (±)-5'-Chloro-5'-deoxy-ENBA

The following data is based on the product molecular weight 379.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.16 mL	26.33 mL
5 mM	0.53 mL	2.63 mL	5.27 mL
10 mM	0.26 mL	1.32 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References for (±)-5'-Chloro-5'-deoxy-ENBA

References are publications that support the biological activity of the product.

Franchetti N⁶-cycloalkyl- and N⁶-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A₁ adenosine receptor with antinociceptive effects in mice. J.Med.Chem. 2009 PMID: 19317449
Trivedi N⁶-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. J.Med.Chem. 1989 PMID: 2909748