6,8-Bis(benzylthio)octanoic acid

Name: 6,8-Bis(benzylthio)octanoic acid
Brand: Tocris Bioscience
SKU: 5348

Tocris Bioscience, part of Bio-Techne | Catalog # 5348

Citations (4)

COA / SDS

PDH and KGDH inhibitor

Key Product Details

Chemical Name:	6,8-Bis[(phenylmethyl)thio]octanoic acid
Purity:	≥99%

View Full Technical Details for 6,8-Bis(benzylthio)octanoic acid

Technical Data
Citations

Biological Activity for 6,8-Bis(benzylthio)octanoic acid

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

Technical Data for 6,8-Bis(benzylthio)octanoic acid

Formula	C₂₂H₂₈O₂S₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	95809-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 6,8-Bis(benzylthio)octanoic acid

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for 6,8-Bis(benzylthio)octanoic acid

References are publications that support the biological activity of the product.

Zachar et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J.Mol.Med. (Berl.), 2011;89:1137 PMID: 21769686
Stuart et al. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab., 2014;2:4 PMID: 24612826
Egawa et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma. PLoS One, 2018;13:e0198940 PMID: 29879220

6,8-Bis(benzylthio)octanoic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 5348

Key Product Details

Biological Activity for 6,8-Bis(benzylthio)octanoic acid

Technical Data for 6,8-Bis(benzylthio)octanoic acid

Solubility for 6,8-Bis(benzylthio)octanoic acid

Dilution Calculator

Reconstitution Calculator

References for 6,8-Bis(benzylthio)octanoic acid

Product Documents for 6,8-Bis(benzylthio)octanoic acid

COA

Certificate of Analysis

SDS

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