6bK

Name: 6bK
Brand: Tocris Bioscience
SKU: 5402

Tocris Bioscience, part of Bio-Techne | Catalog # 5402

Citations (12)

COA / SDS

Insulin degrading enzyme (IDE) inhibitor

Key Product Details

Description:	Insulin degrading enzyme (IDE) inhibitor
Chemical Name:	(3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	757.92

View Full Technical Details for 6bK

Technical Data
Citations

Biological Activity for 6bK

6bK is an insulin degrading enzyme (IDE) inhibitor (IC₅₀ = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.

This compound is supplied in net weight as the TFA salt.

Licensing Information

Sold for research purpose under license from Harvard University

Technical Data for 6bK

M. Wt	757.92
Formula	C₄₁H₅₅N₇O₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1417537-93-9
PubChem ID	91758793
InChi Key	BHZABWWULWHRIY-JAXGQCOVSA-N
Smiles	NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 6bK

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1

Preparing Stock Solutions for 6bK

The following data is based on the product molecular weight 757.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	65.97 mL	329.85 mL	659.70 mL
0.1 mM	13.19 mL	65.97 mL	131.94 mL
0.2 mM	6.60 mL	32.99 mL	65.97 mL
1 mM	1.32 mL	6.60 mL	13.19 mL

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References for 6bK

References are publications that support the biological activity of the product.

Maianti Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones. Nature 2014 PMID: 24847884

6bK