8-pCPT-2-O-Me-cAMP-AM

Biological Activity for 8-pCPT-2-O-Me-cAMP-AM

Technical Data for 8-pCPT-2-O-Me-cAMP-AM

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 8-pCPT-2-O-Me-cAMP-AM

References for 8-pCPT-2-O-Me-cAMP-AM

References are publications that support the biological activity of the product.

• Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, Muller W Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med, 2015;212(7):1021-41. 2015 PMID: 26101266
• KM Alonge, GP Meares, FB Hillgartne Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4 J. Biol. Chem, 2017;0(0):. 2017 PMID: 28188284
• Cyphert H, Alonge K, Ippagunta S, Hillgartner F Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism. PLoS ONE, 2014;9(4):e94996. 2014 PMID: 24733293
• Chepurny et al. Enhanced Rap1 activation and Ins secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J.Biol.Chem., 2009;284:10728 PMID: 19244230
• Tsalkova et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA., 2012;109:18613 PMID: 23091014
• Vliem et al. 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem., 2008;9:2052 PMID: 18633951
• Almahariq et al. A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol., 2013;83:122 PMID: 23066090