A 61603 hydrobromide

Name: A 61603 hydrobromide
Brand: Tocris Bioscience
SKU: 1052
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1052

Citations (19)

COA / SDS

α1A agonist

Key Product Details

Description:	α_1A agonist
Chemical Name:	N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Molecular Weight:	390.29

View Full Technical Details for A 61603 hydrobromide

Technical Data
Citations

Biological Activity for A 61603 hydrobromide

A 61603 hydrobromide is a potent α-adrenoceptor agonist that is at least 35-fold more potent at α_1A than at α_1B or α_1D sites. Induces dose response increases in spontaneous Ca²⁺ transients in rat ventricular myocytes in vitro (EC₅₀ = 6.9 nmol/L).

Technical Data for A 61603 hydrobromide

M. Wt	390.29
Formula	C₁₄H₁₉N₃O₃S.HBr
Storage	Desiccate at +4°C
CAS Number	107756-30-9
PubChem ID	9865178
InChi Key	LRFLWCZMTGTUEP-UHFFFAOYSA-N
Smiles	Br.CS(=O)(=O)NC1=C(O)C=CC2=C1CCCC2C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 61603 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		50

Preparing Stock Solutions for A 61603 hydrobromide

The following data is based on the product molecular weight 390.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.12 mL	25.62 mL	51.24 mL
2.5 mM	1.02 mL	5.12 mL	10.25 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References for A 61603 hydrobromide

References are publications that support the biological activity of the product.

Luo Receptor subtype involved in α_1A-adrenergic receptor-mediated Ca²⁺ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 2007 PMID: 17588332
Meyer Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α_1A receptor agonist. J.Med.Chem. 1996 PMID: 8831777
Knepper A-61603, a potent α₁-adrenergic receptor agonist, selective for the α_1A receptor subtype. J.Pharmacol.Exp.Ther. 1995 PMID: 7616455